Mitochondrial DNA (mtDNA) has two major parts, the control region and the coding region.

The control region is often called the hypervariable region (HVR). Hypervariable means fast changing. In mitochondrial DNA, the control region is the fast changing part. The control region may be further divided into two hypervariable regions, HVR1 and HVR2.

  • HVR1 runs from nucleotide 16001 to nucleotide 16569.
  • HVR2 runs from nucleotide 00001 to nucleotide 00574.

The coding region (CR) is the part of your mtDNA genome that contains genes. Because it does contain some genes, the coding region is believed to be slower mutating than the control region. Often, the mutations that are found in the coding region are used to define haplogroups.

  • The coding region runs from nucleotide 00575 to nucleotide 16000.