The following descriptions provide brief overviews of each main mtDNA haplogroup’s origin and geographic distribution. Haplogroup A Haplogroup A is found in eastern Eurasia and throughout the Americas. This haplogroup was present in the populations […]
To find which version of a heteroplasmic mitochondrial DNA (mtDNA) result is original and which is newer, you need to test other descendants of your direct maternal ancestor. The non-heteroplasmic variant that is most common […]
The Daughters of Eve are named after some of the major haplogroups, but the names are arbitrary. The names usually begin with the same letter as the haplogroup name. We identify the haplogroup itself.
The closeness of a mitochondrial DNA (mtDNA) match depends on the matching level. Matches at higher levels are more likely to be recent. The table below shows the expected time to a common ancestor with […]
The only way to find a connection with your match is by comparing your genealogies. In many cultures, women changed names with marriage. Therefore, it is important to compare geographic locations alongside genealogical information and surnames.
Yes. There are two exceptions to the alphanumeric naming of mitochondrial haplogroups. The first is the use of a zero (0) in the name to indicate that a branch is being inserted between what was a […]
Will my mitochondrial DNA (mtDNA) results show me admixture percentages for ancestry from different lines?
No, because mitochondrial DNA (mtDNA) is inherited exclusively from your direct maternal line, it does not show admixture from your other lines. That is, you received your mitochondrial DNA from your mother, who got it […]
All mitochondrial DNA (mtDNA) mutations go through a state of heteroplasmy. The frequency of heteroplasmy is then equal to or greater than mtDNA mutation rates. Note that population geneticists usually calculate mutation rates using those […]
In each generation, it is possible for the child to inherit the heteroplasmic genome, only the ancestral genome, or only the descendant genome. For each generation, if the mother has a heteroplasmy, each of her […]
Every human cell contains hundreds of mitochondria. Each mitochondrion in a cell contains multiple copies of its own DNA (mtDNA). A new mitochondrial mutation occurs in only one copy of the mtDNA in one mitochondria […]
There is an mtDNA section in Family Tree DNA’s Forums.
To find connections in recent times, it is necessary to find and test multiple people who have suspected shared ancestry. You can do this by careful examination of traditional genealogical records. Making connections with people […]
No. Mothers only pass on those mitochondrial DNA (mtDNA) mutations they inherited from their mothers and new mutations that occur in their eggs. Mutations that occur elsewhere are not inherited.
Yes so far, all direct maternal (mitochondrial DNA) lineages of women alive today trace back to a common ancestor who lived in Africa 100,000 to 180,000 years ago. Further back, the mitochondrial lines of Homo […]
How does the formation of the human egg cell change the frequency of an mtDNA heteroplasmic mutation?
At one point during the process by which the egg cell is produced (oogenesis), the number of mitochondria present in the cell is dramatically reduced from hundreds to perhaps as few as ten. These copies […]
In general, scientists name mitochondrial DNA (mtDNA) haplogroups according to their major branch with a capital letter. They then name subclades (branches) with alternating numbers and letters: H, H1, H1a, H1a1, etc. H H1 H1a […]
As a genealogist, do I really need to understand all of this complex information about mitochondrial DNA (mtDNA) in order to use it for my research?
No. As a genealogist, you may focus on a few basic rules. These will allow you to use mtDNA (mitochondrial DNA) to assist with your traditional genealogical research on maternal lineages. It is best if […]
Mitochondrial DNA (mtDNA) testing covers both recent and distant generations. Matching on HVR1 means that you have a 50% chance of sharing a common maternal ancestor within the last fifty-two generations. That is about 1,300 […]
You will know that one of your mutations or differences from the RSRS is a heteroplasmy by its letter codes. Symbol Meaning Symbol Meaning U U (Uracil) S C or G M A or C […]
We see some mitochondrial DNA mutations more often than others. One mutation which we find often in a number of different haplogroups is C16311T in the HVR1 result. This is a base pair in the […]
Deletions are types of DNA mutations. They are places in your DNA where nucleotides (Cytosine, Guanine, Adenine, and Thymine) have not been copied. The sequence will not have a result for that place. When a […]
Insertions are types of DNA mutations. They are places in your DNA where nucleotides (Cytosine, Guanine, Adenine, and Thymine) have been added to the DNA sequence. In in the example below, the sequence has an […]
Transversions are types of DNA mutations. They are places in your DNA where nucleotides (Cytosine, Guanine, Adenine, and Thymine) have changed value. Transversions are where a purine has mutated to a pyrimidine or where a […]
Transitions are types of DNA mutations. They are places in your DNA where nucleotides (Cytosine, Guanine, Adenine, and Thymine) have changed value. Transitions are where a purine has mutated to the complimentary purine (A <-> […]
Apostrophes are used to create a common branch between two well-established branch points in the tree. One example is M1’20’51. It is the common parent of the M1, M20, and M51 branches. M1’20’51 M1 M20 […]
Zeros are used when a new branch point needs to be inserted above a well-established branch point on the mitochondrial tree. One of the best-known examples of this is the insertion of R0 between the […]
Male sperm contain paternal mitochondria. After cell fertilization, the paternal mitochondria are eliminated from the newly formed zygote.
No, it is not. Over time, some of the genetic code from the mitochondrial genome migrates to the nuclear cell genome. However, enough mitochondrial genetic code remains independently inherited to make mtDNA highly useful for both […]
Mitochondria are specialized subunits (organelle) within cells. In humans, mitochondria are responsible for cell respiration and for producing energy. They evolve into their current state from separate organisms that form a mutually beneficial (symbiotic) relationship […]
Some mitochondrial DNA (mtDNA) haplotypes show a high number of matches. There are two possible explanations for this. Many people with the same results as your ancestors lived thousands or tens of thousands of years […]
If you do not have HVR1 matches, you will not have HVR1 and HVR2 (HVR1,HVR2) combined matches. This is because anyone who is an HVR1,HVR2 match has the same HVR1 result as you. They are […]
You are the first person with your particular HVR1 sequence to be in our database. This can mean that your result is relatively rare and that, as a result, few people have it. It can […]
Family Tree DNA offers mitochondrial DNA (mtDNA) full sequence tests strictly for genealogy and personal ancestry information. Therefore, we do not examine or discuss medical implications of any person’s mtDNA full sequence. In general, the […]
Heteroplasmy is the presence of more than one type of a genome (in this context, mitochondrial DNA) within a cell or organism. Put another way, a heteroplasmy is where more than one result exists for […]
Some mitochondrial DNA (mtDNA) mutations are found throughout the mtDNA tree. This is because the same mutation has happened dozens or hundreds of times in human history.
Mutations are changes to your DNA code. They are natural copying errors. One analogy is to think of a copy machine that is making many copies of a page. Occasionally the printer will make a mistake, for […]
When we test mitochondrial DNA (mtDNA), your results are a list of the four bases that make up DNA, represented by the first letter of their name (Adenine, Thymine, Cytosine, and Guanine). Your results are then compared to […]
The Reconstructed Sapiens Reference Sequence (RSRS) is a mitochondrial DNA (mtDNA) reference sequence that uses both a global sampling of modern human samples and samples from ancient hominids. It was introduced in early 2012 as […]
We use the V14 version of Phylotree published in Behar et al. 2012, A “copernican” reassessment of the human mitochondrial DNA tree from its root. We plan to upgrade to the V15 version as part of […]
Macrohaplogroups (sometimes called supergroups) are the foundation for a number of other haplogroups. They represent older shared ancestors on the maternal tree. Macrohaplogroups link together many of the more common haplogroups that are found today. […]